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‘Knock-back for London’ as one of most valuable companies sells shares directly on rival exchange

Sarah Taylor by Sarah Taylor
September 29, 2025
in Business
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‘Knock-back for London’ as one of most valuable companies sells shares directly on rival exchange
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One of the UK’s most valuable listed companies is to sell its shares directly on the rival New York Stock Exchange, in a move described as a “knock back for London”.

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While AstraZeneca will maintain its headquarters in the UK and its primary stock listing on the London Stock Exchange, the news can be seen as a move away from London.

“Although there has been no suggestion that AstraZeneca is imminently going to up sticks and move its primary listing from London, there may be some nervousness this morning around the risk that the UK market might lose one of its largest constituents,” said Russ Mould, the investment director of investment platform AJ Bell.

Read more:
AstraZeneca exit is a frightening prospect for the City and the government

The news “does at least hint at the possibility of a more dramatic shift at some point in the future”, Mr Mould said.

There may also be relief that AstraZeneca is not moving from the London Stock Exchange altogether.

“I think there is probably relief that it’s not pursuing a primary listing in New York, but the decision is hardly a ringing endorsement of London,” said Neil Wilson, the UK investor strategist at investment platform Saxo Markets.

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“It reflects the fundamental, structural issues in the UK for the largest globally-oriented stocks – the depth and liquidity of its capital markets is falling short of what’s on offer across the pond.”

“It’s also a bit of a knock-back for London”, Mr Wilson said.

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Why is this happening?

The Cambridge-based pharmaceutical company said the decision to sell shares directly on the New York Stock Exchange – rather than the previous less straightforward system of using American depository receipts – has been made to allow it “to reach a broader mix of global investors” and “make it even more attractive for all our shareholders”.

“The US has the world’s largest and most liquid public markets by capitalisation, and the largest pool of innovative biopharma companies and investors,” the company said in an announcement to investors.

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AstraZeneca’s share price was up 0.7% on the news.

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